Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 2/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.53 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705411 | 0.99 | PARP15 (0.54) | PARP15PARP10TNKS2PARP2MAPT | |
| Bromide SCHEMBL10427595 | 0.90 | MAPT (0.59) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL2930357 | 0.88 | MAPT (0.60) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL30753117 | 0.88 | MAPT (0.60) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL20518798 | 0.85 | PARP15 (0.51) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL20518828 | 0.81 | PARP15 (0.47) | PARP15PARP10TNKS2PARP2MAPT | |
| Hydrochloric Acid SCHEMBL10465282 | 0.80 | PARP15 (0.59) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL10427149 | 0.77 | PARP15 (0.48) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL6703523 | 0.76 | PARP15 (0.49) | PARP15PARP10TNKS2PARP2MAPT | |
| SCHEMBL10427152 | 0.75 | PARP15 (0.54) | PARP15PARP10TNKS2PARP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4895863-A | MEMORY DISORDERS | ROUSSEL UCLAF (FR) | 1990-01-23 | — | — | US | disclosed |