Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | ARG2 | P78540 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL10428794 | 1.00 | GSR (0.56) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL21796037 | 0.94 | GSR (0.62) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL10362224 | 0.93 | GSR (0.65) | GSRSLC7A5THRBARG2ARG1 | |
| Lysine SCHEMBL28645968 | 0.93 | GSR (0.65) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL16225160 | 0.93 | GSR (0.65) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL14842041 | 0.90 | GSR (0.57) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL8885822 | 0.89 | GSR (0.59) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL19692952 | 0.89 | GSR (0.59) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL7557531 | 0.89 | GSR (0.59) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL9839934 | 0.89 | GSR (0.43) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | claimed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | claimed |
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | disclosed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | disclosed |