Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.35 |
| ▸ | CDK1 | P06493 | 4/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1042236 | 0.89 | CYP1A2 (0.48) | CYP1A2SMN1; SMN2ALDH1A1CYP2C9NPC1 | |
| SCHEMBL2809390 | 0.84 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2ALDH1A1CYP2C9NPC1 | |
| SCHEMBL2357532 | 0.75 | CYP1A2 (0.50) | CYP1A2SMN1; SMN2ALDH1A1CYP2C9NPC1 | |
| SCHEMBL29572479 | 0.75 | CYP1A2 (0.50) | CYP1A2SMN1; SMN2ALDH1A1CYP2C9NPC1 | |
| SCHEMBL13747649 | 0.75 | CYP1A2 (0.55) | CYP1A2SMN1; SMN2ALDH1A1CYP2C9NPC1 | |
| SCHEMBL658301 | 0.71 | PDE3B (0.59) | CYP1A2CYP2C9CYP11B1CYP11B2GSK3B | |
| SCHEMBL13629292 | 0.70 | CYP1A2 (0.43) | CYP1A2SMN1; SMN2ALDH1A1CYP2C9NPC1 | |
| Bromide SCHEMBL15650437 | 0.70 | PDE3B (0.57) | CYP1A2CYP2C9CYP11B1CYP11B2GSK3B | |
| SCHEMBL11317712 | 0.70 | SRC (0.47) | CYP1A2SMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL2810679 | 0.69 | CDK2 (0.45) | GAAMAPTGSK3BCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835423-B2 | Azepine inhibitors of janus kinases | INCYTE CORPORATION (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2014-01-30 | — | — | US | disclosed |
| US-8563541-B2 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2012-12-27 | — | — | US | disclosed |
| EP-2270014-A1 | Azepine inhibitors of janus kinases | Incyte Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-08-06 | — | — | US | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | CYP1A2 2692/4885SMN1; SMN2 3556/4885ALDH1A1 3705/4885 |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | CYP1A2 2692/4885SMN1; SMN2 3556/4885ALDH1A1 3705/4885 |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | JAK1, JAK3, JAK2 | CYP1A2 2692/4885SMN1; SMN2 3556/4885ALDH1A1 3705/4885 |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | CYP1A2 2692/4885SMN1; SMN2 3556/4885ALDH1A1 3705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.