Sugi Predict

Sugi Predict / Compounds / SCHEMBL1043299

SCHEMBL1043299

SCHEMBL1043299

O=c1[nH]ccc2c(-c3ccc(Cl)cc3)cnc(Nc3ccccc3)c12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 4/20 0.49
▸ JAK1 P23458 3/20 0.49
▸ ZAP70 P43403 2/20 0.48
▸ TTBK1 Q5TCY1 4/20 0.42
▸ TTBK2 Q6IQ55 4/20 0.42
▸ GSK3B P49841 1/20 0.40
▸ BRAF P15056 1/20 0.38
▸ TNNI3K Q59H18 1/20 0.38
▸ FGFR1 P11362 1/20 0.38
▸ EIF4EBP1 Q13541 1/20 0.38
▸ CSNK2A2 P19784 1/20 0.38
▸ CSNK2B P67870 1/20 0.38
▸ CSNK2A1 P68400 1/20 0.38
▸ MAPT P10636 2/20 0.37
▸ TP53 P04637 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ BRD4 O60885 2/20 0.37
▸ THRB P10828 1/20 0.37
▸ ADK P55263 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1049635 0.92 ZAP70 (0.53) JAK2JAK1ZAP70TTBK1TTBK2
SCHEMBL1048999 0.89 ZAP70 (0.49) JAK2JAK1ZAP70TTBK1TTBK2
SCHEMBL1048942 0.88 ZAP70 (0.48) JAK2ZAP70TTBK1TTBK2FGFR1
SCHEMBL1049370 0.88 ZAP70 (0.46) JAK2JAK1ZAP70TTBK1TTBK2
SCHEMBL1049280 0.85 MAPT (0.49) ZAP70TTBK1TTBK2GSK3BBRAF
SCHEMBL1047746 0.85 ZAP70 (0.46) JAK2JAK1ZAP70TTBK1TTBK2
SCHEMBL1048572 0.85 ZAP70 (0.45) JAK2JAK1ZAP70TTBK1TTBK2
SCHEMBL1048920 0.84 CDC7 (0.53) JAK2ZAP70TTBK1TTBK2GSK3B
SCHEMBL1045599 0.84 ZAP70 (0.47) JAK2ZAP70TTBK1TTBK2GSK3B
SCHEMBL27806170 0.84 ZAP70 (0.51) JAK2JAK1ZAP70TTBK1TTBK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546370-B2 Compounds and compositions as kinase inhibitors IRM LLC (BM) 2013-10-01 — — US claimed
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US claimed
EP-2238137-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2010-10-13 — — EP claimed
WO-2009097287-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2009-08-06 — — WO claimed
US-8546370-B2 Compounds and compositions as kinase inhibitors IRM LLC (BM) 2013-10-01 — — US disclosed
CN-101990539-A Compounds and compositions as kinase inhibitors IRM LLC 2011-03-23 — — CN disclosed
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US disclosed
EP-2238137-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2010-10-13 — — EP disclosed
WO-2009097287-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2009-08-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FYN, SYK, RET JAK2 63/4885JAK1 90/4885ZAP70 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.