Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 3/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1041739 | 0.82 | KDM1A (0.44) | ALKBH5FTOKDM1AMAOAMAOB | |
| SCHEMBL1252143 | 0.78 | KDM1A (0.50) | ALKBH5FTOKDM1AMAOAMAOB | |
| SCHEMBL1230498 | 0.76 | MC4R (0.57) | ALKBH5FTOKDM1AMAOAMAOB | |
| SCHEMBL16709819 | 0.75 | ABL1 (0.53) | MAOAMAOBHDAC1HDAC8ABL1 | |
| SCHEMBL31369927 | 0.74 | HDAC1 (0.49) | ALKBH5FTOKDM1AMAOAMAOB | |
| SCHEMBL23023032 | 0.73 | GAA (0.53) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL1230497 | 0.73 | HDAC1 (0.48) | ALKBH5FTOKDM1AMAOAMAOB | |
| SCHEMBL8666600 | 0.72 | HDAC1 (0.55) | KDM1AMAOAMAOBHDAC1HDAC8 | |
| SCHEMBL13428865 | 0.71 | KDM1A (0.47) | ALKBH5FTOKDM1AMAOAMAOB | |
| SCHEMBL1570966 | 0.71 | KDM1A (0.47) | ALKBH5FTOKDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725528-B1 | SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2013-05-29 | — | — | EP | claimed |
| WO-2019043176-A2 | HDAC INHIBITOR IN COMBINATION WITH ANTIMETABOLITE AGENT FOR CANCER THERAPY | 4SC AG (DE) | 2019-03-07 | — | — | WO | disclosed |
| US-8969401-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2015-03-03 | — | — | US | disclosed |
| EP-1725528-B1 | SULPHONYLPYRROLES AS HDAC INHIBITORS | 4SC AG (DE) | 2013-05-29 | — | — | EP | disclosed |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | ALTANA PHARMA AG (DE) | 2013-03-28 | — | — | US | disclosed |
| US-8399505-B2 | Sulfonylpyrroles | 4SC AG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8232297-B2 | Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles | 4SC AG (DE) | 2012-07-31 | — | — | US | disclosed |
| US-8188138-B2 | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors | 4SC AG (DE) | 2012-05-29 | — | — | US | disclosed |
| US-8067615-B2 | Sulphonylpyrroles | 4SC AG (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20110166140-A1 | NOVEL SULPHONYLPYRROLES | MAIER THOMAS | 2011-07-07 | — | — | US | disclosed |
| US-20100261761-A1 | Novel Sulfonylpyrroles | MAIER THOMAS | 2010-10-14 | — | — | US | disclosed |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | NYCOMED GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | NYCOMED GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| EP-1928872-A1 | NOVEL SULPHONYLPYRROLES AS INHIBITORS OF HDAC S NOVEL SULPHONYLPYRROLES | Nycomed GmbH (DE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1928826-A1 | SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASES INHIBITORS | Nycomed GmbH (DE) | 2008-06-11 | — | — | EP | disclosed |
| US-20070184979-A1 | Novel sulfonylpyrroles | ALTANA PHARMA AG (DE) | 2007-08-09 | — | — | US | disclosed |
| WO-2007039404-A1 | NOVEL SULPHONYLPYRROLES AS INHIBITORS OF HDAC S NOVEL SULPHONYLPYRROLES | NYCOMED GMBH (DE) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007039403-A1 | SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASES INHIBITORS | NYCOMED GMBH (DE) | 2007-04-12 | — | — | WO | disclosed |
| EP-1725528-A2 | SULPHONYLPYRROLES AS HDAC INHIBITORS | Altana Pharma AG (DE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005087724-A2 | SULPHONYLPYRROLES AS HDAC INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263353-A1 | Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles | HDAC1, HDAC3, HDAC2 | ALKBH5 2063/4885FTO 2187/4885KDM1A 43/4885 |
| US-20070184979-A1 | Novel sulfonylpyrroles | HDAC1, HDAC4, HDAC3 | ALKBH5 2295/4885FTO 1350/4885KDM1A 17/4885 |
| US-20110166140-A1 | NOVEL SULPHONYLPYRROLES | HDAC1, HDAC3, HDAC2 | ALKBH5 1738/4885FTO 1530/4885KDM1A 37/4885 |
| US-20100261761-A1 | Novel Sulfonylpyrroles | HDAC3, HDAC1, HDAC2 | ALKBH5 3268/4885FTO 2752/4885KDM1A 42/4885 |
| US-20090297473-A1 | Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors | HDAC1, HDAC3, HDAC2 | ALKBH5 2223/4885FTO 1996/4885KDM1A 30/4885 |
| US-20130079347-A1 | NOVEL SULFONYLPYRROLES | HDAC3, HDAC1, HDAC2 | ALKBH5 3268/4885FTO 2752/4885KDM1A 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.