Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.48 |
| ▸ | REN | P00797 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9578954 | 0.87 | KLK5 (0.53) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL7355735 | 0.85 | KLK5 (0.56) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL7355740 | 0.85 | KLK5 (0.56) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL10445666 | 0.85 | KLK5 (0.47) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL15005230 | 0.83 | KLK5 (0.65) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL1601995 | 0.83 | KLK5 (0.65) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL1602032 | 0.83 | KLK5 (0.65) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL3031552 | 0.83 | KLK5 (0.65) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL15005231 | 0.83 | KLK5 (0.65) | KLK5ATMCTSSCTSKCTSL | |
| SCHEMBL6556253 | 0.82 | KLK5 (0.53) | KLK5ATMCTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356595-A1 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-07 | — | — | EP | disclosed |