Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392856 | 0.87 | KLK5 (0.67) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10722177 | 0.86 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6430793 | 0.86 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3361485 | 0.85 | KLK5 (0.63) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL720790 | 0.84 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9394616 | 0.84 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5619596 | 0.84 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5861336 | 0.83 | KLK5 (0.61) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7797841 | 0.82 | KLK5 (0.62) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7299571 | 0.82 | ATM (0.62) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0386611-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-12 | — | — | EP | disclosed |