SCHEMBL10449643

SCHEMBL10449643

c1cnc2sc3c(-n4c5ccccc5c5cc(-n6c7ccccc7c7cc(-n8c9ccccc9c9ccccc98)ccc76)ccc54)cccc3c2c1

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ CLK1 P49759 2/20 0.34
▸ LIMK1 P53667 2/20 0.34
▸ CDC7 O00311 1/20 0.34
▸ DBF4 Q9UBU7 1/20 0.34
▸ PIK3CA P42336 2/20 0.33
▸ EGFR P00533 1/20 0.32
▸ KAT2B Q92831 3/20 0.32
▸ TLR5 O60602 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ PRKCQ Q04759 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18158867 0.89 KDM4E (0.40) KDM4EATML3MBTL1CLK1LIMK1
SCHEMBL25751949 0.88 KDM4E (0.34) KDM4EATML3MBTL1ALDH1A1
SCHEMBL25751947 0.88 KDM4E (0.34) KDM4EATML3MBTL1ALDH1A1
SCHEMBL25751943 0.88 KDM4E (0.34) KDM4EATML3MBTL1ALDH1A1
SCHEMBL23622674 0.86 KDM4E (0.43) KDM4EATML3MBTL1ALDH1A1
SCHEMBL21671319 0.86 KDM4E (0.43) KDM4EATML3MBTL1ALDH1A1
SCHEMBL16326605 0.86 — —
SCHEMBL1701682 0.84 TLR5 (0.34) KDM4EATML3MBTL1CLK1LIMK1
SCHEMBL10449645 0.83 CLK1 (0.33) KDM4EATML3MBTL1CLK1LIMK1
SCHEMBL17038030 0.83 CLK1 (0.33) KDM4EATML3MBTL1CLK1LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8221905-B2 Carbazole-containing materials in phosphorescent light emitting diodes UNIVERSAL DISPLAY CORPORATION (US) 2012-07-17 — — US disclosed
US-20090153034-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTINIG DIODES UNIVERSAL DISPLAY CORPORATION (US) 2009-06-18 — — US disclosed
US-20090134784-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES UNIVERSAL DISPLAY CORPORATION (US) 2009-05-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090134784-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES OXA1L, PAICS, ORC3 KDM4E 3635/4885ATM 3627/4885L3MBTL1 111/4885
US-20090153034-A1 CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTINIG DIODES PAICS, CYBA, OXA1L KDM4E 3607/4885ATM 3690/4885L3MBTL1 279/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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