Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.44 |
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10450345 | 1.00 | SLC6A2 (0.44) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Oxalic Acid SCHEMBL10450343 | 1.00 | SLC6A2 (0.44) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL10451875 | 0.94 | SLC6A4 (0.45) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL10452095 | 0.94 | SLC6A4 (0.45) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL10450341 | 0.94 | SLC6A4 (0.45) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL10452094 | 0.94 | SLC6A4 (0.45) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL10451874 | 0.94 | SLC6A4 (0.45) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL10452101 | 0.93 | SLC6A4 (0.44) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL10452099 | 0.93 | SLC6A4 (0.44) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL10452100 | 0.93 | SLC6A4 (0.44) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4910323-A | Chlorination using n-chlorosuccinimide | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4847414-A | INTERMEDIATES FOR ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0077536-B1 | 2'-SUBSTITUTED-SPIRO(BENZOFURAN-2(3H),1'-CYCLOALKANES), A PROCESS FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4594435-A | ANTIDEPRESSANTS; ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1986-06-10 | — | — | US | disclosed |
| US-4517311-A | 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4404221-A | ANALGESICS AND ATNIDEPRESSANTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-09-13 | — | — | US | disclosed |
| EP-0077536-A2 | 2'-Substituted-spiro(benzofuran-2(3H),1'-cycloalkanes), a process for preparing same, pharmaceutical compositions containing such compounds and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-04-27 | — | — | EP | disclosed |