Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSL1 | P33121 | 2/20 | 0.54 |
| ▸ | ACSL6 | Q9UKU0 | 2/20 | 0.54 |
| ▸ | XDH | P47989 | 3/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453885 | 0.95 | ACSL1 (0.51) | ACSL1ACSL6XDHLTB4RKDM4E | |
| SCHEMBL10454060 | 0.91 | PARP10 (0.51) | ACSL1ACSL6LTB4RKDM4EALDH1A1 | |
| SCHEMBL10452831 | 0.90 | ACSL1 (0.49) | ACSL1ACSL6XDHLTB4RKDM4E | |
| SCHEMBL10454274 | 0.89 | TP53 (0.62) | ACSL1ACSL6XDHLTB4RKDM4E | |
| SCHEMBL10454184 | 0.89 | ACSL1 (0.50) | ACSL1ACSL6XDHLTB4RKDM4E | |
| SCHEMBL10454142 | 0.88 | ACSL1 (0.48) | ACSL1ACSL6XDHLTB4RKDM4E | |
| SCHEMBL11862585 | 0.85 | TP53 (0.69) | ACSL1ACSL6XDHLTB4RKDM4E | |
| SCHEMBL10454065 | 0.85 | KMT2A (0.62) | ACSL1ACSL6XDHLTB4RKDM4E | |
| SCHEMBL10452771 | 0.84 | KDM4E (0.66) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL10453903 | 0.84 | KMT2A (0.61) | ACSL1ACSL6XDHLTB4RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902701-A | Tetrazolyl substituted tricyclic compounds and pharmacological compositions thereof | BURROUGHS WELCOME CO. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0093381-B1 | TRICYCLIC COMPOUNDS, PREPARATION, USE AND INTERMEDIATES | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |
| EP-0093381-A1 | Tricyclic compounds, preparation, use and intermediates | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-11-09 | — | — | EP | disclosed |