Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 20/20 | 0.47 |
| ▸ | RARG | P13631 | 20/20 | 0.47 |
| ▸ | RARA | P10276 | 18/20 | 0.47 |
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10671081 | 1.00 | RARB (0.47) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10453034 | 0.96 | RARG (0.47) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10670949 | 0.96 | RARG (0.47) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10453035 | 0.91 | RARB (0.46) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10670698 | 0.91 | RARB (0.46) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10674665 | 0.90 | RARB (0.45) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10452947 | 0.90 | RARB (0.45) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10667170 | 0.87 | RARG (0.47) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10453041 | 0.87 | RARG (0.47) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL10673555 | 0.87 | RARG (0.46) | RARBRARGRARARXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0176032-B1 | TETRALIN DERIVATIVES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1990-03-07 | — | — | EP | disclosed |
| US-4760174-A | Tetralin derivatives, their preparation and their use | BASF AKTIENGESELLSCHAFT (DE) | 1988-07-26 | — | — | US | disclosed |
| EP-0176032-A2 | Tetralin derivatives, their preparation and use | BASF Aktiengesellschaft (DE) | 1986-04-02 | — | — | EP | disclosed |