Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cortivazol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 18/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cortivazol SCHEMBL21340660 | 0.99 | KDM4E (0.82) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| Cortivazol SCHEMBL4875 | 0.99 | KDM4E (0.82) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| Cortivazol SCHEMBL6820239 | 0.99 | KDM4E (0.81) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| Cortivazol SCHEMBL4969166 | 0.94 | KDM4E (0.74) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL22946293 | 0.93 | KDM4E (0.71) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL11946698 | 0.93 | KDM4E (0.71) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL21340662 | 0.92 | KDM4E (0.70) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL21231563 | 0.91 | KDM4E (0.69) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL29610995 | 0.90 | KDM4E (0.85) | KDM4EMEN1KMT2ANPSR1NR3C1 | |
| SCHEMBL22946295 | 0.90 | KDM4E (0.67) | KDM4EMEN1KMT2ANPSR1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959208-A | ULTRAHIGH MOLECULAR WEIGHT POLYETHYLENE OR POLYPROPYLENE | PPG INDUSTRIES, INC. (US) | 1990-09-25 | — | — | US | disclosed |