SCHEMBL10459902

SCHEMBL10459902

Cc1ccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 19/20 0.73
LMNA P02545 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10459904 1.00 PTAFR (0.73) PTAFRLMNA
SCHEMBL10459218 0.91 PTAFR (0.78) PTAFRLMNA
SCHEMBL10459217 0.91 PTAFR (0.78) PTAFRLMNA
SCHEMBL10459204 0.89 PTAFR (0.74) PTAFRLMNA
SCHEMBL10459522 0.86 PTAFR (0.73) PTAFRLMNA
SCHEMBL10459523 0.86 PTAFR (0.73) PTAFRLMNA
SCHEMBL10459775 0.86 PTAFR (0.76) PTAFR
SCHEMBL10459774 0.86 PTAFR (0.76) PTAFR
SCHEMBL10458061 0.85 PTAFR (1.00) PTAFR
SCHEMBL10458059 0.85 PTAFR (1.00) PTAFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4916145-A PLATELET ACTIVATING FACTOR ANTAGONISTS HOFFMANN-LA ROCHE INC. (US) 1990-04-10 US disclosed