Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172668 | 0.85 | MAPT (0.44) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL2612388 | 0.84 | KMT2A (0.49) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL11991767 | 0.82 | MAPT (0.47) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL21917390 | 0.80 | — | — | |
| SCHEMBL10466181 | 0.80 | NPC1 (0.54) | KMT2AMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL10067956 | 0.79 | GAA (0.55) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL9382083 | 0.78 | AOC3 (0.48) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL15080346 | 0.78 | MAPT (0.44) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL11991383 | 0.78 | MAPT (0.44) | KMT2AMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL10466126 | 0.77 | MAPT (0.50) | KMT2AMAPTMEN1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |