Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aztreonam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aztreonam SCHEMBL10674684 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL16863406 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL4459605 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL4469609 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL9424911 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL37512 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL37511 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL26423 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL14209115 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR | |
| Aztreonam SCHEMBL10516547 | 1.00 | ESR1 (1.00) | ESR1USP2KDM4ENR1I2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048953-B1 | BETA-LACTAM ANTIBIOTICS | E.R. Squibb & Sons, Inc. (US) | 1988-03-09 | — | — | EP | claimed |
| EP-0048953-A2 | Beta-lactam antibiotics | E.R. Squibb & Sons, Inc. (US) | 1982-04-07 | — | — | EP | claimed |
| US-4948898-A | MICROBIOCIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4652651-A | Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0200159-A2 | 3-Acylamino-2-oxo-1-azetidinesulfonic acids | E.R. Squibb & Sons, Inc. (US) | 1986-11-05 | — | — | EP | disclosed |