Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.54 |
| ▸ | YES1 | P07947 | 3/20 | 0.54 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HIPK1 | Q86Z02 | 2/20 | 0.45 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1049116 | 0.90 | CLK1 (0.58) | KDRABL1NTRK1YES1ZAP70 | |
| SCHEMBL1047617 | 0.88 | ZAP70 (0.54) | KDRZAP70ROCK1SRCMAPT | |
| SCHEMBL1047358 | 0.88 | ZAP70 (0.49) | KDRABL1NTRK1YES1ZAP70 | |
| SCHEMBL1049307 | 0.88 | ZAP70 (0.56) | KDRABL1NTRK1YES1ZAP70 | |
| SCHEMBL1043457 | 0.86 | ZAP70 (0.52) | ZAP70ROCK1MAPTKDM4EALDH1A1 | |
| SCHEMBL1043429 | 0.85 | ROCK1 (0.60) | ZAP70ROCK1SRCCLK1MAPT | |
| SCHEMBL1049683 | 0.84 | ZAP70 (0.76) | KDRABL1NTRK1YES1ZAP70 | |
| SCHEMBL1048699 | 0.83 | ZAP70 (0.54) | ZAP70ROCK1MAPK1MAPTKDM4E | |
| SCHEMBL1047996 | 0.81 | ITK (0.54) | KDRABL1NTRK1YES1ZAP70 | |
| SCHEMBL1047448 | 0.81 | ZAP70 (0.54) | ZAP70ROCK1SRCMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546370-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-10-01 | — | — | US | claimed |
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | claimed |
| US-8546370-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-10-01 | — | — | US | disclosed |
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | disclosed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | FYN, SYK, RET | KDR 18/4885ABL1 11/4885NTRK1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.