Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CD44 | P16070 | 2/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334518 | 0.82 | CYP1A2 (0.48) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL9585880 | 0.80 | CYP1A2 (0.32) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL7284478 | 0.75 | CYP1A2 (0.47) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL7299893 | 0.75 | CD44 (0.58) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL7293331 | 0.73 | CYP1A2 (0.46) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL7290160 | 0.70 | CYP1A2 (0.45) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL7300802 | 0.69 | CYP1A2 (0.45) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL7363572 | 0.68 | CYP1A2 (0.48) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL7360303 | 0.68 | CYP1A2 (0.41) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C | |
| SCHEMBL8962724 | 0.67 | CYP1A2 (0.63) | CYP1A2CYP3A4ADRA2CHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| EP-0306323-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1994-09-21 | — | — | EP | disclosed |
| EP-0306323-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1989-03-08 | — | — | EP | disclosed |