Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 14/20 | 0.67 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1049401 | 0.89 | ZAP70 (0.85) | ZAP70JAK1JAK3 | |
| SCHEMBL1045821 | 0.81 | ZAP70 (1.00) | ZAP70JAK1JAK3 | |
| SCHEMBL1047354 | 0.81 | ZAP70 (0.81) | ZAP70JAK1EGFR | |
| SCHEMBL1043425 | 0.80 | ZAP70 (0.60) | ZAP70JAK1LCKEGFRJAK3 | |
| SCHEMBL1045636 | 0.77 | ZAP70 (0.72) | ZAP70JAK1EGFR | |
| SCHEMBL1048148 | 0.77 | ZAP70 (0.76) | ZAP70JAK1EGFR | |
| SCHEMBL1046480 | 0.77 | ZAP70 (0.61) | ZAP70JAK1 | |
| SCHEMBL1043305 | 0.76 | ZAP70 (0.80) | ZAP70 | |
| SCHEMBL1048857 | 0.76 | ZAP70 (0.80) | ZAP70JAK1 | |
| SCHEMBL1046871 | 0.76 | ZAP70 (0.76) | ZAP70JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546370-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-10-01 | — | — | US | disclosed |
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | FYN, SYK, RET | ZAP70 4/4885JAK1 90/4885LCK 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.