Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.48 |
| ▸ | PDE4A | P27815 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11192353 | 0.88 | KCNH2 (0.53) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10472724 | 0.88 | KCNH2 (0.53) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10999826 | 0.87 | KCNH2 (0.55) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10992462 | 0.86 | KCNH2 (0.51) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10990539 | 0.86 | PDE3B (0.53) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10474310 | 0.86 | PDE3B (0.53) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10990884 | 0.86 | KCNH2 (0.51) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11479531 | 0.85 | KCNH2 (0.56) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11487896 | 0.85 | KCNH2 (0.56) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10474613 | 0.85 | PDE3B (0.52) | KCNH2PDE3BSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4965263-A | HYPOTENSIVE AGENTS | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1990-10-23 | — | — | US | disclosed |
| US-4639451-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS | MITSUI TOATSU KAGAKU-KABUSHIKI KAISHA (JP) | 1987-01-27 | — | — | US | disclosed |
| US-4544562-A | 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, and their use as anti-hypertensive and anti-thrombocyte agents | BASF AKTIENGESELLSCHAFT (DE) | 1985-10-01 | — | — | US | disclosed |
| EP-0107735-A1 | NOVEL PYRIDAZINONE DERIVATIVES | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1984-05-09 | — | — | EP | disclosed |
| EP-0089528-A1 | 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, their preparation and use | BASF Aktiengesellschaft (DE) | 1983-09-28 | — | — | EP | disclosed |