Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.69 |
| ▸ | FLT4 | P35916 | 1/20 | 0.69 |
| ▸ | GSK3B | P49841 | 1/20 | 0.69 |
| ▸ | RARB | P10826 | 1/20 | 0.69 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | XBP1 | P17861 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
| ▸ | DPP4 | P27487 | 6/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13576345 | 1.00 | KMT2A (0.70) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9043957 | 1.00 | KMT2A (0.70) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9045050 | 0.90 | KMT2A (0.56) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL10512615 | 0.90 | KMT2A (0.56) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9147028 | 0.88 | EPHA2 (0.71) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9147035 | 0.88 | EPHA2 (0.71) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9149691 | 0.85 | KMT2A (0.86) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9043188 | 0.85 | KMT2A (0.54) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL10514084 | 0.85 | KMT2A (0.54) | KMT2AEPHA2FLT4GSK3BRARB | |
| Trovafloxacin1 SCHEMBL9734048 | 0.84 | EPHA2 (0.72) | KMT2AEPHA2FLT4GSK3BRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4962112-A | 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds | ABBOTT LABORATORIES (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0302371-A2 | 7-(2-Methyl-4-aminopyrrolidinyl)naphthyridine and quinoline compounds | ABBOTT LABORATORIES (US) | 1989-02-08 | — | — | EP | disclosed |