Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10474019 | 0.88 | GALR3 (0.54) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| SCHEMBL10474289 | 0.84 | GALR3 (0.53) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| SCHEMBL7268664 | 0.83 | GALR3 (0.63) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| SCHEMBL7266508 | 0.80 | GALR3 (0.67) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| SCHEMBL7273854 | 0.79 | GALR3 (0.60) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| Iodide SCHEMBL10474072 | 0.79 | GALR3 (0.74) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| Iodide SCHEMBL10475228 | 0.79 | GALR3 (0.58) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| Iodide SCHEMBL10475514 | 0.79 | MAPT (0.44) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| SCHEMBL16157089 | 0.79 | MAPT (0.67) | GALR3MAPTSMN1; SMN2THRBPDE3B | |
| SCHEMBL7266917 | 0.78 | GALR3 (0.66) | GALR3MAPTSMN1; SMN2THRBPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4968683-A | INOTROPIC, CARDIOTONIC | HEUMANN PHARMA GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |