SCHEMBL10485673

SCHEMBL10485673

Nc1nc(N)c(N)c(NCc2ccccc2)n1

nearest known ligand 0.64

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
APP P05067 10/20 0.64
CDK1 P06493 2/20 0.55
DHFR P00374 2/20 0.54
NPSR1 Q6W5P4 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.50
CHUK O15111 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6362020 0.85 APP (0.62) APPCDK1DHFRNPSR1SMN1; SMN2
SCHEMBL3422229 0.83 APP (0.60) APPCDK1NPSR1SMN1; SMN2CHUK
SCHEMBL13009791 0.78 APP (1.00) APPNPSR1
Hydrochloric Acid SCHEMBL5478228 0.77 APP (0.67) APPNPSR1
SCHEMBL3301514 0.76 NPSR1 (0.74) APPDHFRNPSR1SMN1; SMN2
SCHEMBL6727019 0.76 NPSR1 (0.74) APPDHFRNPSR1SMN1; SMN2
SCHEMBL6128301 0.74 APP (0.57) APPCDK1NPSR1
Hydrochloric Acid SCHEMBL9247173 0.74 NPSR1 (0.72) APPDHFRNPSR1SMN1; SMN2
SCHEMBL11582812 0.73 APP (0.56) APPCDK1NPSR1SMN1; SMN2
SCHEMBL9643328 0.73 MAPT (0.58) DHFRCHUK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4838893-A AND TETRAAMINOPYRIDINES ASDEVELOPER COMPONENTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1989-06-13 US disclosed
US-4684371-A Oxidation hair dyes comprising m-phenylenediamine derivatives as coupling components HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1987-08-04 US disclosed
US-4575377-A Oxidation hair dyes comprising resorcinol derivatives as coupling components HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1986-03-11 US disclosed
US-4552565-A Hair dyes: diresorcyl sulphide, sulphoxide or sulphone coupling agents HENKEL KGAA (DE) 1985-11-12 US disclosed
US-4371370-A Oxidation hair dyes comprising bis-(2,4-diaminophenoxy)-alkanols as coupling components HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1983-02-01 US disclosed
US-4325704-A CONTAINING A DEVELOPER AND AN N-BENZYL-M-PHENYLENEDIAMINE DERIVATIVE AS A COUPLER HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1982-04-20 US disclosed
US-4322212-A AS COUPLERS WITH CONVENTIONAL DEVELOPERS IN AQUEOUS SOLUTION HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1982-03-30 US disclosed
US-4213758-A Oxidation hair dyes based upon tetraaminopyrimidine developers and couplers therefor HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1980-07-22 US disclosed
US-RE30199-E Oxidation hair dyes based upon tetraaminopyrimidine developers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1980-01-29 US disclosed
US-4171203-A IN COMBINATION WITH A TETRAAMINOPYRIMIDING COUPLER SURFACTANTS AND THICKENERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1979-10-16 US disclosed
US-4168953-A Oxidation hair dyes based upon tetraaminopyrimidine developers and monohydroxyindazole couplers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1979-09-25 US disclosed
US-4129413-A Oxidation hair dyes based upon tetraaminopyrimidine developers and mono- and dialkyl -m- dihydroxy benzene couplers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1978-12-12 US disclosed
US-4003699-A Oxidation hair dyes based upon tetraaminopyrimidine developers HENKEL & CIE G.M.B.H. (DT) 1977-01-18 US disclosed