Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.61 |
| ▸ | PPARA | Q07869 | 17/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29163290 | 0.90 | PPARG (0.65) | PPARGPPARAPTPN1 | |
| SCHEMBL9128242 | 0.87 | PPARG (0.59) | PPARGPPARAPTPN1 | |
| SCHEMBL23124906 | 0.86 | PTPN1 (0.56) | PPARGPPARAPTPN1 | |
| SCHEMBL9128983 | 0.86 | PPARG (0.74) | PPARGPPARA | |
| SCHEMBL9818821 | 0.85 | PPARG (0.76) | PPARGPPARA | |
| SCHEMBL9818882 | 0.84 | PPARG (0.60) | PPARGPPARAPTPN1 | |
| SCHEMBL5992928 | 0.82 | PPARG (0.76) | PPARGPPARA | |
| SCHEMBL3972453 | 0.82 | PPARG (0.62) | PPARGPPARAPTPN1 | |
| SCHEMBL2175270 | 0.82 | PSMB5 (0.48) | PPARGPPARAPTPN1 | |
| SCHEMBL2175262 | 0.82 | PSMB5 (0.48) | PPARGPPARAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |