Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818947 | 0.91 | AKR1B1 (0.72) | AKR1B1 | |
| SCHEMBL10712670 | 0.89 | AKR1B1 (0.75) | AKR1B1 | |
| SCHEMBL10487484 | 0.88 | AKR1B1 (0.73) | AKR1B1 | |
| SCHEMBL10487520 | 0.88 | AKR1B1 (0.76) | AKR1B1 | |
| SCHEMBL10487448 | 0.87 | AKR1B1 (0.74) | AKR1B1 | |
| SCHEMBL10487444 | 0.86 | AKR1B1 (0.77) | AKR1B1 | |
| SCHEMBL10487557 | 0.86 | AKR1B1 (0.73) | AKR1B1 | |
| SCHEMBL10487490 | 0.85 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL10487451 | 0.83 | AKR1B1 (0.71) | AKR1B1 | |
| SCHEMBL10487462 | 0.82 | AKR1B1 (0.73) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |