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Sugi Predict / Compounds / SCHEMBL1048898

SCHEMBL1048898

SCHEMBL1048898

Cn1ccc2cc(Nc3nccs3)nc(N)c2c1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 2/20 0.39
▸ SRC P12931 1/20 0.39
▸ BTK Q06187 1/20 0.39
▸ ZAP70 P43403 1/20 0.37
▸ SMN1; SMN2 Q16637 4/20 0.37
▸ HPGD P15428 2/20 0.37
▸ SCN9A Q15858 1/20 0.37
▸ ALDH1A1 P00352 4/20 0.34
▸ LMNA P02545 3/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ TDP1 Q9NUW8 2/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ EDNRA P25101 1/20 0.34
▸ SLC6A4 P31645 1/20 0.34
▸ ADRA1A P35348 1/20 0.34
▸ PRMT6 Q96LA8 1/20 0.34
▸ MAPK9 P45984 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ PLA2G7 Q13093 1/20 0.33
▸ PIK3CB P42338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1049156 0.81 ZAP70 (0.40) SYKZAP70PIK3CB
SCHEMBL1043458 0.79 TYK2 (0.42) SYKSRCBTKZAP70ALDH1A1
SCHEMBL1047675 0.78 GSK3A (0.41) SRCBTKZAP70SCN9A
SCHEMBL1049135 0.78 SYK (0.44) SYKSRCBTKZAP70SMN1; SMN2
SCHEMBL27806125 0.77 TLR7 (0.42) SYKZAP70HPGDADORA2A
SCHEMBL12874416 0.76 ZAP70 (0.37) SYKZAP70
SCHEMBL1049396 0.76 ZAP70 (0.39) SYKZAP70SMN1; SMN2HPGDALDH1A1
SCHEMBL1043575 0.76 LRRK2 (0.42) SYKBTKZAP70SMN1; SMN2ALDH1A1
SCHEMBL1048765 0.75 BTK (0.43) SRCBTKZAP70
SCHEMBL1048022 0.75 BTK (0.39) SYKBTKZAP70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546370-B2 Compounds and compositions as kinase inhibitors IRM LLC (BM) 2013-10-01 — — US claimed
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US claimed
US-8546370-B2 Compounds and compositions as kinase inhibitors IRM LLC (BM) 2013-10-01 — — US disclosed
US-8546370-B2 Compounds and compositions as kinase inhibitors IRM LLC (BM) 2013-10-01 — — US disclosed
US-8546370-B2 Compounds and compositions as kinase inhibitors IRM LLC (BM) 2013-10-01 — — US disclosed
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US disclosed
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US disclosed
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US disclosed
EP-2238137-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2010-10-13 — — EP disclosed
WO-2009097287-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS IRM LLC (BM) 2009-08-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110003798-A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FYN, SYK, RET SYK 2/4885SRC 31/4885BTK 24/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.