Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Felbamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | PKM | P14618 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089944 | 0.95 | CYP1A2 (0.83) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| SCHEMBL7775772 | 0.95 | CYP1A2 (0.83) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| Felbamate SCHEMBL34947 | 0.93 | CYP1A2 (1.00) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| Felbamate SCHEMBL2946508 | 0.93 | CYP1A2 (1.00) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| Felbamate SCHEMBL7153063 | 0.91 | CYP1A2 (0.96) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| Felbamate SCHEMBL17597519 | 0.91 | CYP1A2 (0.96) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| Sulfamate SCHEMBL8914106 | 0.87 | CYP1A2 (0.71) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| Sulfamate SCHEMBL8822869 | 0.87 | CYP1A2 (0.71) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| Sulfamate SCHEMBL8913325 | 0.87 | CYP1A2 (0.71) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 | |
| SCHEMBL8392180 | 0.85 | CYP1A2 (0.83) | CYP1A2SMN1; SMN2CYP2D6PKMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2273993-A1 | METHODS AND COMPOSITIONS FOR THE INTRACEREBROVENTRICULAR ADMINISTRATION OF FELBAMATE | The Regents of the University of Colorado, A Body Corporate (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-2180884-A1 | CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS | The Regents of the University of Colorado, a body corporate (US) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009151741-A1 | METHODS AND COMPOSITIONS FOR THE INTRACEREBROVENTRICULAR ADMINISTRATION OF FELBAMATE | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009014762-A1 | CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2009-01-29 | — | — | WO | disclosed |