Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10491666 | 0.96 | MAPT (0.49) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27165109 | 0.96 | MAPT (0.49) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27165041 | 0.96 | MAPT (0.49) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27165108 | 0.96 | MAPT (0.49) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10491674 | 0.96 | MAPT (0.49) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10491694 | 0.96 | MAPT (0.49) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10491678 | 0.95 | MAPT (0.48) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10491685 | 0.95 | MAPT (0.48) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| Methyl Alcohol SCHEMBL11009975 | 0.92 | MAPT (0.46) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 | |
| Toluene SCHEMBL10491969 | 0.91 | MAPT (0.46) | MAPTHPGDKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820734-A | ANALGESICS,ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0138030-A2 | Phenylethylamine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-04-24 | — | — | EP | disclosed |