Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | DHODH | Q02127 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10499303 | 1.00 | NPSR1 (0.63) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5622061 | 0.90 | NPSR1 (0.72) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9650819 | 0.86 | NPSR1 (0.67) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9650815 | 0.86 | NPSR1 (0.67) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL18999575 | 0.86 | NPSR1 (0.67) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9650924 | 0.83 | NPSR1 (0.63) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9652064 | 0.83 | NPSR1 (0.63) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9650927 | 0.83 | NPSR1 (0.63) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9652061 | 0.83 | NPSR1 (0.63) | NPSR1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL29254508 | 0.82 | DHODH (0.64) | NPSR1RAB9AGAADHODHCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4806549-A | INHIBITOR OF GASTRIC ACID SECRETION | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4806550-A | 4-Amino-3-carbonyl substituted quinolines as inhibitors of gastric acid secretion | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-21 | — | — | US | disclosed |
| WO-1988001621-A1 | 4-AMINOQUINOLINE DERIVATIVES AND THEIR USE AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-03-10 | — | — | WO | disclosed |
| EP-0259174-A1 | Derivatives of 4-aminoquinoline and their use as medicaments | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-03-09 | — | — | EP | disclosed |