Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10395957 | 0.99 | ELANE (0.43) | ELANECYP2D6SYKCYP11B2POLB | |
| SCHEMBL10395836 | 0.87 | ELANE (0.49) | ELANECYP2D6SYKPOLBMEN1 | |
| Hydrochloric Acid SCHEMBL10396434 | 0.86 | ELANE (0.48) | ELANECYP2D6SYKPOLBMEN1 | |
| SCHEMBL10737898 | 0.84 | ELANE (0.47) | ELANECYP2D6SYKKDM4EALDH1A1 | |
| SCHEMBL10738773 | 0.84 | ELANE (0.50) | ELANEMEN1KMT2A | |
| SCHEMBL10396614 | 0.83 | ELANE (0.50) | ELANEMEN1KMT2A | |
| SCHEMBL10739040 | 0.83 | ELANE (0.50) | ELANEPOLBMEN1KMT2ACNR1 | |
| SCHEMBL1545547 | 0.83 | GAA (0.43) | CYP2D6SYKALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10396421 | 0.83 | ELANE (0.47) | ELANECYP2D6SYKKDM4EALDH1A1 | |
| SCHEMBL10735833 | 0.82 | BCHE (0.53) | CYP2D6SYKALDH1A1HTR2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135781-B1 | 3-(PIPERIDINYL)- AND 3-(PYRROLIDINYL)-1H-INDAZOLES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICAMENT | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-10-11 | — | — | EP | claimed |
| US-4670447-A | ANALGESICS, ANTIDEPRESSANTS, ANTICONVULSANTS AND HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-02 | — | — | US | claimed |
| EP-0135781-A1 | 3-(Piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles, a process for their preparation and their use as a medicament | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-04-03 | — | — | EP | claimed |