Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 11/20 | 0.43 |
| ▸ | GAA | P10253 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501198 | 0.85 | NOX1 (0.51) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL10500416 | 0.76 | NOX1 (0.47) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL10500800 | 0.74 | NOX1 (0.38) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL20444659 | 0.74 | NOX1 (0.52) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL10558875 | 0.73 | ELANE (0.43) | NOX1GAAMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10501359 | 0.73 | NOX1 (0.38) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL10500786 | 0.72 | MAPT (0.44) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL10505587 | 0.71 | NOX1 (0.52) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL28704963 | 0.67 | NOX1 (0.81) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL30622722 | 0.67 | NOX1 (0.50) | NOX1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4876246-A | Benzo[a]phenothiazines and hydro-derivatives for inhibiting leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1989-10-24 | — | — | US | disclosed |
| EP-0136893-B1 | Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them | MERCK FROSST CANADA INC. (CA) | 1989-08-16 | — | — | EP | disclosed |
| US-4611056-A | Benzo[A]phenothiazines and hydro-derivatives | MERCK FROSST CANADA, INC. (CA) | 1986-09-09 | — | — | US | disclosed |
| EP-0136893-A2 | Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them | MERCK FROSST CANADA INC. (CA) | 1985-04-10 | — | — | EP | disclosed |