Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.45 |
| ▸ | TSHR | P16473 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13691987 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL27756335 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL27756333 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL28580670 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL27756338 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL12540247 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL4658795 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL13534716 | 0.83 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL20263087 | 0.83 | CYP3A4 (0.45) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL20263084 | 0.83 | CYP3A4 (0.45) | CYP3A4TSHRALDH1A1SMN1; SMN2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0111326-B1 | PROCESS FOR THE MANUFACTURE OF CHIRAL AZETIDINONES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-01-11 | — | — | EP | claimed |
| EP-0111326-A1 | Process for the manufacture of chiral azetidinones | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-06-20 | — | — | EP | claimed |
| EP-0111326-B1 | PROCESS FOR THE MANUFACTURE OF CHIRAL AZETIDINONES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-01-11 | — | — | EP | disclosed |
| US-4663469-A | 4-hydroxy-l-threoninamides | HOFFMAN-LA ROCHE INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4502994-A | Enantiomeric synthesis of 3-amino-4-carbamoyloxymethyl-2-azetidonone-1-sulfate | HOFFMANN-LA ROCHE INC. (US) | 1985-03-05 | — | — | US | disclosed |