Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18680966 | 0.79 | KDM4E (0.49) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL6472344 | 0.78 | TSHR (0.50) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL9073570 | 0.76 | TSHR (0.58) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL8592890 | 0.75 | KDM4E (0.53) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL18712396 | 0.75 | KDM4E (0.56) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL95926 | 0.75 | KDM4E (0.56) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL13557891 | 0.75 | KDM4E (0.56) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL11277660 | 0.74 | CYP2C9 (0.50) | TSHRALDH1A1IDO1LMNACYP1A2 | |
| SCHEMBL23273064 | 0.74 | TSHR (0.45) | POLBKDM4ETSHRCA1CA2 | |
| SCHEMBL11146323 | 0.73 | TSHR (0.67) | POLBKDM4ETSHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0165289-B1 | NOVEL DERIVATIVES OF GUANINE | Medivir Aktiebolag (SE) | 1989-04-05 | — | — | EP | disclosed |
| US-4798833-A | VIRICIDES | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1989-01-17 | — | — | US | disclosed |
| EP-0165289-A1 | NOVEL DERIVATIVES OF GUANINE. | ASTRA LAEKEMEDEL AB (SE) | 1985-12-27 | — | — | EP | disclosed |
| WO-1985002845-A1 | NOVEL DERIVATIVES OF GUANINE | Astra Läkemedel Aktiebolag (SE) | 1985-07-04 | — | — | WO | disclosed |
| EP-0146516-A2 | Derivatives of Guanine, process for their preparation and a pharmaceutical preparation | Astra Läkemedel Aktiebolag (SE) | 1985-06-26 | — | — | EP | disclosed |