SCHEMBL10508019

SCHEMBL10508019

CC(C)(C)N(I)CC(O)COc1nsnc1N1CCOCC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.67
ADRB2 P07550 1/20 0.67
ADRB1 P08588 1/20 0.67
CYP3A4 P08684 1/20 0.67
HTR1A P08908 1/20 0.67
CYP2D6 P10635 1/20 0.67
ADRB3 P13945 1/20 0.67
NFKB1 P19838 1/20 0.67
DRD1 P21728 1/20 0.67
SIGMAR1 Q99720 1/20 0.67
TDP1 Q9NUW8 1/20 0.67
SMN1; SMN2 Q16637 1/20 0.58
BLM P54132 1/20 0.58
HTT P42858 2/20 0.48
NPSR1 Q6W5P4 1/20 0.48
KMT2A Q03164 5/20 0.48
ALDH1A1 P00352 6/20 0.47
ALOX15 P16050 2/20 0.47
HSD17B10 Q99714 2/20 0.47
HPGD P15428 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22970806 0.89 CYP1A2 (0.69) CYP1A2ADRB2ADRB1CYP3A4HTR1A
SCHEMBL22486699 0.88 CYP1A2 (0.68) CYP1A2ADRB2ADRB1CYP3A4HTR1A
SCHEMBL24859257 0.86 CYP1A2 (0.66) CYP1A2ADRB2ADRB1CYP3A4HTR1A
SCHEMBL20511540 0.84 CYP1A2 (0.63) CYP1A2ADRB2ADRB1CYP3A4HTR1A
SCHEMBL20511541 0.84 CYP1A2 (0.63) CYP1A2ADRB2ADRB1CYP3A4HTR1A
SCHEMBL18908562 0.81 CYP1A2 (0.71) CYP1A2ADRB2ADRB1CYP3A4HTR1A
SCHEMBL19870486 0.81 CYP1A2 (0.71) CYP1A2ADRB2ADRB1CYP3A4HTR1A
Timolol SCHEMBL2553603 0.80 CYP1A2 (1.00) CYP1A2ADRB2ADRB1CYP3A4HTR1A
Timolol SCHEMBL222970 0.80 CYP1A2 (1.00) CYP1A2ADRB2ADRB1CYP3A4HTR1A
Timolol SCHEMBL4912 0.80 CYP1A2 (1.00) CYP1A2ADRB2ADRB1CYP3A4HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0152340-B1 2-Sulfamoylbenzo[b]furan derivatives and ophtalmic composition for the treatment of elevated intraocular pressure MERCK & CO. INC. (US) 1989-05-10 EP disclosed