Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.49 |
| ▸ | TYMS | P04818 | 4/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10506884 | 0.89 | HPRT1 (0.48) | HPRT1TYMSXDH | |
| SCHEMBL10506438 | 0.89 | HPRT1 (0.48) | HPRT1TYMSMAPT | |
| SCHEMBL4144591 | 0.88 | HPRT1 (0.50) | HPRT1TYMSPNP | |
| SCHEMBL10507502 | 0.88 | TYMS (0.51) | HPRT1TYMSXDHPNP | |
| SCHEMBL10506935 | 0.87 | MAPT (0.50) | HPRT1TYMSXDHMAPTPNP | |
| SCHEMBL10506681 | 0.85 | HPRT1 (0.48) | HPRT1TYMSPNP | |
| SCHEMBL10507491 | 0.85 | HPRT1 (0.46) | HPRT1TYMS | |
| SCHEMBL10508847 | 0.85 | TYMS (0.51) | HPRT1TYMSXDHPNP | |
| SCHEMBL9798295 | 0.81 | PNP (0.47) | HPRT1TYMSPNP | |
| SCHEMBL9798311 | 0.81 | HPRT1 (0.47) | HPRT1TYMSMAPTPNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874862-A | Process for preparing guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0156559-A2 | 8-Substituted guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-10-02 | — | — | EP | disclosed |