Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.64 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6355139 | 0.84 | CYP4F2 (0.66) | CYP4F2CYP4A11CYP2D6OPRK1POLB | |
| SCHEMBL5847599 | 0.83 | CYP2D6 (0.53) | CYP4F2CYP4A11CYP2D6OPRK1 | |
| SCHEMBL5847604 | 0.83 | CYP2D6 (0.53) | CYP4F2CYP4A11CYP2D6OPRK1 | |
| SCHEMBL5847594 | 0.83 | CYP2D6 (0.53) | CYP4F2CYP4A11CYP2D6OPRK1 | |
| SCHEMBL13230299 | 0.81 | CYP4F2 (0.75) | CYP4F2CYP4A11POLBHPGDKMT2A | |
| SCHEMBL10508228 | 0.80 | CYP4F2 (0.73) | CYP4F2CYP4A11POLBKMT2AALDH1A1 | |
| SCHEMBL11564119 | 0.79 | POLB (0.44) | CYP4F2CYP4A11POLBHPGDRECQL | |
| SCHEMBL908570 | 0.79 | CYP4F2 (0.72) | CYP4F2CYP4A11OPRK1POLBKMT2A | |
| SCHEMBL10506066 | 0.79 | CYP4F2 (0.72) | CYP4F2CYP4A11POLBHPGDKMT2A | |
| SCHEMBL6846728 | 0.79 | CYP4F2 (0.72) | CYP4F2CYP4A11OPRK1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0145067-B1 | DERIVATIVES OF 2,2'-IMINOBISETHANOL | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-25 | — | — | EP | disclosed |
| US-4654362-A | CARDIOVASCULAR DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-03-31 | — | — | US | disclosed |
| EP-0145067-A2 | Derivatives of 2,2'-iminobisethanol | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |