Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | TPO | P07202 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10505548 | 0.89 | TYMS (0.46) | TYMSHPRT1PNP | |
| SCHEMBL10506793 | 0.88 | TYMS (0.40) | TYMSHPRT1SMN1; SMN2PNPALDH1A1 | |
| SCHEMBL9503635 | 0.88 | PNP (0.47) | TYMSHPRT1NOS1PNP | |
| SCHEMBL10509001 | 0.87 | HPRT1 (0.47) | TYMSHPRT1BRDTNOS1HPGD | |
| SCHEMBL10507792 | 0.85 | TYMS (0.50) | TYMSHPRT1HPGDPNPALDH1A1 | |
| SCHEMBL10508808 | 0.85 | HPRT1 (0.38) | TYMSHPRT1NOS1PNPALDH1A1 | |
| SCHEMBL9665364 | 0.81 | PNP (0.45) | HPRT1NOS1PNPALDH1A1 | |
| SCHEMBL10644971 | 0.81 | HPRT1 (0.38) | TYMSHPRT1NOS1PNPALDH1A1 | |
| SCHEMBL10385954 | 0.80 | PNP (0.44) | HPRT1PNPALDH1A1 | |
| SCHEMBL10646878 | 0.77 | HPRT1 (0.37) | TYMSHPRT1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | claimed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | claimed |
| EP-0156559-A2 | 8-Substituted guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1985-10-02 | — | — | EP | claimed |
| US-4874862-A | Process for preparing guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| EP-0156559-B1 | 8-SUBSTITUTED GUANINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4748177-A | Guanine derivatives | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |