Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 9/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10516627 | 1.00 | PREP (0.49) | PREPNPSR1HSD17B10NPC1TDP1 | |
| SCHEMBL10518352 | 0.93 | PREP (0.48) | PREPNPSR1HSD17B10NPC1ACE | |
| SCHEMBL10518345 | 0.93 | PREP (0.48) | PREPNPSR1HSD17B10NPC1ACE | |
| SCHEMBL10516263 | 0.82 | PREP (0.72) | PREPNPSR1HSD17B10NPC1FKBP1A | |
| SCHEMBL10516273 | 0.82 | PREP (0.72) | PREPNPSR1HSD17B10NPC1FKBP1A | |
| SCHEMBL10516349 | 0.81 | ACE (0.50) | PREPNPC1TDP1ACEPOLB | |
| SCHEMBL10516360 | 0.81 | ACE (0.50) | PREPNPC1TDP1ACEPOLB | |
| SCHEMBL10527487 | 0.80 | PREP (0.67) | PREPNPC1TDP1POLB | |
| SCHEMBL10527479 | 0.80 | PREP (0.67) | PREPNPC1TDP1POLB | |
| SCHEMBL10516524 | 0.78 | PREP (0.65) | PREPNPC1TDP1POLBFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4857524-A | Thiazolidine compounds and therapeutic method | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | claimed |
| US-4857524-A | Thiazolidine compounds and therapeutic method | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0303434-A1 | Thiazolidine compounds | Kissei Pharmaceutical Co. Ltd. (JP) | 1989-02-15 | — | — | EP | disclosed |