⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747279 | 1.00 | — | — | |
| SCHEMBL14747638 | 1.00 | — | — | |
| SCHEMBL15684458 | 1.00 | — | — | |
| SCHEMBL13654911 | 1.00 | — | — | |
| SCHEMBL984959 | 1.00 | — | — | |
| SCHEMBL6101587 | 1.00 | — | — | |
| SCHEMBL13841808 | 1.00 | — | — | |
| SCHEMBL29571910 | 0.92 | GAA (0.36) | — | |
| SCHEMBL5126049 | 0.92 | GAA (0.36) | — | |
| SCHEMBL19764396 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250353838-A1 | METHOD FOR PREPARING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE | PINOTBIO, INC. (KR) | 2025-11-20 | — | — | US | disclosed |
| EP-4524145-A1 | METHOD FOR PREPARING 4?-THIO-5-AZA-2?-DEOXYCYTIDINE | Pinotbio, Inc. (KR) | 2025-03-19 | — | — | EP | disclosed |
| EP-3833668-B1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-19 | — | — | EP | disclosed |
| US-11993602-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-05-28 | — | — | US | disclosed |
| CN-117460736-A | Nucleoside derivatives having multi-target phosphorylase inhibitory activity and pharmaceutical compositions for preventing and treating cancer comprising the same | 未来制药有限公司 | 2024-01-26 | — | — | CN | disclosed |
| WO-2023239190-A1 | METHOD FOR PREPARING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE | 주식회사 피노바이오 | 2023-12-14 | — | — | WO | disclosed |
| WO-2023239190-A1 | METHOD FOR PREPARING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE | 주식회사 피노바이오 | 2023-12-14 | — | — | WO | disclosed |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20210277009-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-09-09 | — | — | US | disclosed |
| US-20100324277-A1 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100324277-A1 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100324277-A1 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| EP-1677822-A4 | 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2007098597-A1 | GLYCOSIDASE INHIBITORS AND METHODS OF SYNTHESIZING SAME | SIMON FRASER UNIVERSITY (CA) | 2007-09-07 | — | — | WO | disclosed |
| US-20060247222-A1 | Glycosidase inhibitors and methods of synthesizing same | SIMON FRASER UNIVERSITY (CA) | 2006-11-02 | — | — | US | disclosed |
| WO-2005027962-A9 | 4’-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2006-08-10 | — | — | WO | disclosed |
| EP-1677822-A2 | 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2006-07-12 | — | — | EP | disclosed |
| US-20050130923-A1 | Nucleosides; RNA interference; gene expression inhibition; for use in therapeutic, diagnostic, and research applications involving gene silencing | IONIS PHARMACEUTICALS, INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2005027962-A1 | 4’-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |