Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.66 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.66 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.55 |
| ▸ | CDK9 | P50750 | 2/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 9/20 | 0.52 |
| ▸ | PIM1 | P11309 | 3/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949572 | 0.88 | NTRK1 (0.69) | NTRK1NTRK3NTRK2FYNPIM1 | |
| SCHEMBL13234539 | 0.87 | NTRK1 (0.70) | NTRK1NTRK3NTRK2FYNPIM1 | |
| SCHEMBL2942579 | 0.84 | NTRK1 (0.67) | NTRK1NTRK3NTRK2DYRK1ADYRK2 | |
| SCHEMBL2951116 | 0.84 | FYN (0.67) | NTRK1NTRK3NTRK2FYNPIM1 | |
| SCHEMBL102929 | 0.84 | NTRK1 (0.64) | NTRK1NTRK3NTRK2FYNPIM1 | |
| SCHEMBL2945213 | 0.83 | NTRK1 (0.68) | NTRK1NTRK3NTRK2FYNPIM1 | |
| SCHEMBL2947680 | 0.82 | PIM1 (0.77) | NTRK1NTRK3NTRK2PIM1RET | |
| SCHEMBL2943263 | 0.82 | NTRK1 (0.66) | NTRK1NTRK3NTRK2FYNPIM1 | |
| SCHEMBL1054219 | 0.81 | PIM1 (0.71) | NTRK1NTRK3NTRK2FYNPIM1 | |
| SCHEMBL1051240 | 0.81 | FYN (0.71) | NTRK1NTRK3NTRK2FYNPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021513-A1 | MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | BIOGEN IDEC MA INC. (US) | 2011-01-27 | — | — | US | claimed |
| US-20110021513-A1 | MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | BIOGEN IDEC MA INC. (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021513-A1 | MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | IRAK1, IRAK2, IRAK3 | NTRK1 750/4885NTRK3 896/4885NTRK2 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.