Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549293 | 0.91 | FASN (0.49) | TSHRFASNCHRM2CHRM4CHRM1 | |
| SCHEMBL10552720 | 0.90 | TSHR (0.48) | TSHRFASNCHRM2CHRM4CHRM1 | |
| SCHEMBL10550839 | 0.89 | TSHR (0.47) | TSHRFASNCHRM2CHRM4CHRM1 | |
| SCHEMBL10550836 | 0.89 | TSHR (0.47) | TSHRFASNCHRM2CHRM4CHRM1 | |
| SCHEMBL10548589 | 0.88 | TSHR (0.46) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10550449 | 0.88 | TSHR (0.46) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10556430 | 0.88 | TSHR (0.46) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL10551160 | 0.85 | FASN (0.44) | TSHRFASNSLC6A2SLC6A3 | |
| SCHEMBL10552694 | 0.85 | FASN (0.44) | TSHRFASNSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16591212 | 0.85 | FASN (0.44) | TSHRFASNSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4818431-A | ELECTROOPTICAL DISPLAY ELEMENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-04-04 | — | — | US | disclosed |
| EP-0117476-B1 | TETRAHYDROPYRANES | MERCK PATENT GmbH (DE) | 1987-09-16 | — | — | EP | disclosed |
| EP-0117476-A1 | Tetrahydropyranes | MERCK PATENT GmbH (DE) | 1984-09-05 | — | — | EP | disclosed |