Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PLA2G6 | O60733 | 2/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10550635 | 0.99 | TP53 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10551958 | 0.99 | TP53 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10550936 | 0.99 | TP53 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10556375 | 0.99 | TP53 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10550974 | 0.97 | TP53 (0.41) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10551884 | 0.96 | SPHK1 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10552781 | 0.96 | SPHK1 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10548567 | 0.96 | SPHK1 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10551180 | 0.96 | SPHK1 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL10551566 | 0.96 | SPHK1 (0.43) | HPGDNPC1TP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4818431-A | ELECTROOPTICAL DISPLAY ELEMENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-04-04 | — | — | US | disclosed |
| EP-0117476-B1 | TETRAHYDROPYRANES | MERCK PATENT GmbH (DE) | 1987-09-16 | — | — | EP | disclosed |
| EP-0117476-A1 | Tetrahydropyranes | MERCK PATENT GmbH (DE) | 1984-09-05 | — | — | EP | disclosed |