Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10552304 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE3BPDE3ALMNAPDE4B | |
| SCHEMBL7277988 | 0.73 | PDE3B (0.60) | SMN1; SMN2PDE3BPDE3ALMNAPDE4B | |
| SCHEMBL11254453 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE3BPDE3ALMNAPDE4B | |
| SCHEMBL2788049 | 0.70 | CYP2A6 (0.44) | SMN1; SMN2LMNAALOX5APCYP2A6GRM4 | |
| SCHEMBL10911962 | 0.68 | SMN1; SMN2 (0.53) | SMN1; SMN2PDE3BPDE3ALMNAPDE4B | |
| SCHEMBL7152208 | 0.68 | CYP2A6 (0.53) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17103799 | 0.66 | SMN1; SMN2 (0.56) | SMN1; SMN2PDE3BPDE3ALMNAPDE4B | |
| SCHEMBL29935775 | 0.65 | CYP2A6 (0.47) | SMN1; SMN2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9826144 | 0.65 | CYP2A6 (0.47) | SMN1; SMN2LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8237489 | 0.65 | CYP2A6 (0.44) | SMN1; SMN2CYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |