Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438561 | 0.82 | MAPT (0.52) | RAB9A | |
| SCHEMBL9468851 | 0.79 | HPGD (0.41) | HTR2CKDM4EALDH1A1IDO1SCN2A | |
| SCHEMBL10461071 | 0.79 | RPS6KB1 (0.40) | HTR2CKDM4EALDH1A1IDO1SCN2A | |
| SCHEMBL9468466 | 0.76 | KDM4E (0.50) | HTR2CKDM4EALDH1A1IDO1SCN2A | |
| SCHEMBL9870769 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL8337425 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1NPC1RAB9ANR3C1 | |
| SCHEMBL10554628 | 0.72 | CNR2 (0.44) | KDM4EALDH1A1NPC1RAB9ACNR2 | |
| SCHEMBL10557157 | 0.72 | POLB (0.44) | HTR2CKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10557976 | 0.71 | CSNK1E (0.42) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5442258 | 0.70 | DDR2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |