Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HTR1D | P28221 | 4/20 | 0.52 |
| ▸ | HTR1B | P28222 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10741943 | 0.93 | MAPT (0.71) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10773888 | 0.92 | GAA (0.69) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10716615 | 0.86 | GAA (0.68) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10494781 | 0.86 | MAPT (0.66) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10716480 | 0.86 | GAA (0.67) | GAAMAPTMEN1KMT2ANPC1 | |
| Methane SCHEMBL10718816 | 0.85 | GAA (0.67) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL2535334 | 0.85 | GAA (0.73) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10716519 | 0.85 | GAA (0.69) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10747542 | 0.83 | GAA (0.64) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10745299 | 0.83 | GAA (0.64) | GAAMAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4839377-A | TREATMENT OF MIGRAINE | GLAXO GROUP LIMITED (GB) | 1989-06-13 | — | — | US | disclosed |
| US-4672067-A | 5-substituted 3-aminoalkyl indoles useful in treatment of migraine | GLAXO GROUP LIMITED (GB) | 1987-06-09 | — | — | US | disclosed |
| US-4636521-A | ANALGESICS | GLAXO GROUP LIMITED (GB) | 1987-01-13 | — | — | US | disclosed |