Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 6/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.38 |
| ▸ | GSK3A | P49840 | 4/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659375 | 0.78 | AHR (0.48) | BRD4PLCG1PDE3BPDE3AGSK3B | |
| SCHEMBL29550002 | 0.78 | AHR (0.48) | BRD4PLCG1PDE3BPDE3AGSK3B | |
| SCHEMBL3053419 | 0.77 | MAPT (0.53) | BRD4PLCG1PDE3BPDE3AGSK3B | |
| SCHEMBL2066798 | 0.77 | CYP11B1 (0.44) | BRD4PLCG1PDE3BPDE3AGSK3B | |
| SCHEMBL2233893 | 0.77 | NPC1 (0.50) | BRD4PLCG1PDE3BPDE3AGSK3B | |
| SCHEMBL30493623 | 0.77 | NPC1 (0.50) | BRD4PLCG1PDE3BPDE3AGSK3B | |
| SCHEMBL279914 | 0.74 | CYP11B1 (0.44) | GSK3BCDK5CDK5R1GSK3ACYP11B1 | |
| SCHEMBL29561576 | 0.74 | CYP11B1 (0.44) | GSK3BCDK5CDK5R1GSK3ACYP11B1 | |
| SCHEMBL12387707 | 0.73 | MAPT (0.43) | BRD4PLCG1MAPTAHRPDK2 | |
| Hydrochloric Acid SCHEMBL30693477 | 0.72 | CYP11B1 (0.43) | GSK3BCDK5CDK5R1GSK3ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4866074-A | Naphtheridinone- and pyridooxazinone-pyridone compounds, cardiotonic compositions including same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| US-4829066-A | CONGESTIVE HEART FAILURE | RORER PHARMACEUTICAL CORPORATION (US) | 1989-05-09 | — | — | US | disclosed |
| US-4822794-A | Pyridooxazinone-pyridone compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1989-04-18 | — | — | US | disclosed |