Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406058 | 0.79 | OPRL1 (0.65) | OPRL1POLBCCR3TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL7401723 | 0.77 | POLB (0.66) | OPRL1POLBCCR3TSHRCYP2C19 | |
| SCHEMBL12931241 | 0.75 | OPRL1 (0.39) | OPRL1POLBCCR3TSHRCYP2C19 | |
| SCHEMBL1366704 | 0.73 | OPRL1 (0.65) | OPRL1POLBCCR3TSHRCYP2C19 | |
| SCHEMBL11616084 | 0.72 | CCR3 (0.67) | OPRL1POLBCCR3KMT2AALDH1A1 | |
| SCHEMBL4832242 | 0.72 | CHRM2 (0.56) | OPRL1POLBFAAHCYP2C19ALDH1A1 | |
| SCHEMBL5399810 | 0.71 | MEN1 (0.57) | OPRL1POLBCCR3KMT2AMEN1 | |
| SCHEMBL6208208 | 0.71 | POLB (0.66) | OPRL1POLBCCR3ALDH1A1LMNA | |
| SCHEMBL1314774 | 0.71 | OPRL1 (0.63) | OPRL1POLBCCR3TSHRCYP2C19 | |
| SCHEMBL1990088 | 0.71 | OPRL1 (0.63) | OPRL1POLBCCR3TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254888-B1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | MSD KK (JP) | 2014-12-24 | — | — | EP | disclosed |
| EP-2254888-B1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | MSD KK (JP) | 2014-12-24 | — | — | EP | disclosed |
| US-8519136-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2013-08-27 | — | — | US | disclosed |
| US-8519136-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2013-08-27 | — | — | US | disclosed |
| US-8519136-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2013-08-27 | — | — | US | disclosed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-2254888-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009104802-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009104802-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003833-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | AURKA, AURKC, AURKB | OPRL1 3742/4885POLB 3398/4885FAAH 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.