Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.65 |
| ▸ | SYK | P43405 | 9/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.46 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048639 | 0.88 | ZAP70 (0.83) | ZAP70SYKMAP4K1MAP4K3BRD4 | |
| SCHEMBL1055198 | 0.83 | SYK (0.62) | ZAP70SYK | |
| SCHEMBL1059394 | 0.82 | ZAP70 (0.64) | ZAP70SYKMAP4K1MAP4K3BRD4 | |
| SCHEMBL1059804 | 0.82 | ZAP70 (0.61) | ZAP70SYKMAP4K1MAP4K3 | |
| SCHEMBL1058891 | 0.81 | ZAP70 (0.62) | ZAP70SYKMAP4K1MAP4K3 | |
| SCHEMBL1048411 | 0.79 | ZAP70 (0.79) | ZAP70SYKBRD4CREBBP | |
| SCHEMBL1047037 | 0.79 | ZAP70 (1.00) | ZAP70SYKBRD4CREBBP | |
| SCHEMBL1048726 | 0.79 | ZAP70 (0.80) | ZAP70SYK | |
| SCHEMBL1044257 | 0.79 | ZAP70 (0.76) | ZAP70SYK | |
| SCHEMBL1047856 | 0.79 | ZAP70 (0.78) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354526-B2 | Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors | IRM LLC (BM) | 2013-01-15 | — | — | US | claimed |
| US-20110003790-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | claimed |
| US-8354526-B2 | Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors | IRM LLC (BM) | 2013-01-15 | — | — | US | disclosed |
| US-20110003790-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003790-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | ZAP70, FLT3, LCK | ZAP70 1/4885SYK 18/4885MAP4K1 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.