Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 10/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10573588 | 0.93 | AKR1B1 (0.45) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10579227 | 0.91 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL10576212 | 0.91 | AKR1B1 (0.48) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10571505 | 0.86 | AKR1B1 (0.62) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10578197 | 0.85 | AKR1B1 (0.46) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10373488 | 0.82 | AKR1B1 (0.63) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL10576515 | 0.79 | AKR1B1 (0.59) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10575580 | 0.79 | AKR1B1 (0.48) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10574757 | 0.77 | AKR1B1 (0.65) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL10574425 | 0.76 | AKR1B1 (0.47) | AKR1B1AKR1B10AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874869-A | TREATMENT OF DIABETIC COMPLICATIONS, CATARACTS | EISAI CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |
| US-4780472-A | Hydantoin derivatives for treating complications of diabetes | EISAI CO., LTD. (JP) | 1988-10-25 | — | — | US | disclosed |
| US-4540704-A | Treating complications of diabetes mellitus with hydantoin derivatives | EISAI CO., LTD. (JP) | 1985-09-10 | — | — | US | disclosed |