Sugi Predict

Sugi Predict / Compounds / SCHEMBL1058077

SCHEMBL1058077

SCHEMBL1058077

O=c1[nH]cnc2cc(Cl)nc(Nc3ccc(N4CCOCC4)nc3)c12

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 4/20 0.47
▸ JAK1 P23458 1/20 0.45
▸ JAK3 P52333 1/20 0.45
▸ JAK2 O60674 5/20 0.43
▸ ZAP70 P43403 4/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ PTK6 Q13882 1/20 0.42
▸ PIK3CD O00329 1/20 0.42
▸ PIK3CA P42336 1/20 0.42
▸ PIK3CB P42338 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ IGF1R P08069 1/20 0.42
▸ SRC P12931 1/20 0.41
▸ FLT3 P36888 1/20 0.41
▸ EGFR P00533 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12962038 0.89 PTK6 (0.50) SYKJAK1JAK3JAK2ZAP70
SCHEMBL1047700 0.88 SYK (0.57) SYKJAK2ZAP70MAPTSMN1; SMN2
SCHEMBL14641820 0.86 SYK (0.45) SYKJAK1JAK3JAK2ZAP70
SCHEMBL12932360 0.85 ZAP70 (0.45) SYKJAK1JAK3JAK2ZAP70
SCHEMBL1058717 0.84 ZAP70 (0.46) SYKJAK1JAK3JAK2ZAP70
SCHEMBL1057874 0.84 ZAP70 (0.46) SYKJAK1JAK3JAK2ZAP70
SCHEMBL1057174 0.84 ZAP70 (0.62) SYKJAK1JAK3JAK2ZAP70
SCHEMBL1053641 0.84 SYK (0.56) SYKJAK1JAK3JAK2ZAP70
SCHEMBL13746494 0.83 ZAP70 (0.45) SYKJAK1JAK3JAK2ZAP70
SCHEMBL1059805 0.83 SYK (0.53) SYKJAK1JAK3JAK2ZAP70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8354526-B2 Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors IRM LLC (BM) 2013-01-15 — — US disclosed
US-8354526-B2 Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors IRM LLC (BM) 2013-01-15 — — US disclosed
US-8354526-B2 Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors IRM LLC (BM) 2013-01-15 — — US disclosed
US-20110003790-A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US disclosed
US-20110003790-A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US disclosed
US-20110003790-A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2011-01-06 — — US disclosed
EP-2250169-A1 PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2010-11-17 — — EP disclosed
WO-2009099801-A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2009-08-13 — — WO disclosed
WO-2009099801-A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS IRM LLC (BM) 2009-08-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110003790-A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS ZAP70, FLT3, LCK SYK 18/4885JAK1 45/4885JAK3 57/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.