Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30342352 | 0.88 | NR1H2 (0.49) | NR1H2PDE4BUSP2SMN1; SMN2HPGD | |
| SCHEMBL10137666 | 0.88 | NR1H2 (0.49) | NR1H2PDE4BUSP2SMN1; SMN2HPGD | |
| SCHEMBL25608131 | 0.88 | NR1H2 (0.49) | NR1H2PDE4BUSP2SMN1; SMN2HPGD | |
| SCHEMBL10137667 | 0.88 | NR1H2 (0.49) | NR1H2PDE4BUSP2SMN1; SMN2HPGD | |
| SCHEMBL10137713 | 0.88 | NR1H2 (0.49) | NR1H2PDE4BUSP2SMN1; SMN2HPGD | |
| SCHEMBL24707902 | 0.88 | NR1H2 (0.49) | NR1H2PDE4BUSP2SMN1; SMN2HPGD | |
| SCHEMBL1052921 | 0.86 | NR1H2 (0.53) | NR1H2PDE4BUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL20905506 | 0.86 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL1051376 | 0.86 | NR1H2 (0.53) | NR1H2PDE4BUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL6065186 | 0.86 | NR1H2 (0.53) | NR1H2PDE4BUSP2SMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322034-A2 | Methyl tetrahydropyridyl oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-06-28 | — | — | EP | disclosed |